An MRI study of Chlamydia pneumoniae infection in Italian multiple sclerosis patients
Identifieur interne : 003296 ( Main/Exploration ); précédent : 003295; suivant : 003297An MRI study of Chlamydia pneumoniae infection in Italian multiple sclerosis patients
Auteurs : L Me Grimaldi [Italie] ; A. Pincherle [Italie] ; F. Martinelli-Boneschi [Italie] ; M. Filippi [Italie] ; F. Patti [Italie] ; A. Reggio [Italie] ; D. Franciotta [Italie] ; L. Allegra [Italie] ; G. Comi [Italie] ; F. Blasi [Italie]Source :
- Multiple Sclerosis [ 1352-4585 ] ; 2003-10.
English descriptors
- Teeft :
- Amplification techniques, Cerebrospinal, Cerebrospinal fluid, Chlamydia, Chlamydia pneumoniae, Chlamydia pneumoniae infection, Clin microbiol, Clinical evaluation, Clinical relapse, Clinical specimens, Covariance analysis, Disease duration, Disease onset, Eds, Edss score, Latter hypothesis, Lesion, Lesional, Lesional load, Lumbar puncture, Mult scler, Multiple sclerosis, Neurol, Neurological controls, Ormerod score, Pneumoniae, Polymerase chain reaction, Sclerosis, Template preparation.
Abstract
We amplified sequences of the Chlamydia pneumoniae (C P) major-outer membrane protein in the cerebrospinal fluid (CSF) from 23 of 107 (21.5%) relapsing-remitting or secondary progressive multiple sclerosis (MS) patients and two of 77 (2.6%) patients with other neurological diseases (OND) (P =0.00022). C P+ patients showed magnetic resonance imaging (MRI) evidence of more active disease (P =0.02) compared to CP-MS patients and tended to have an anticipation of age at disease onset (32.39-12 versus 28.59-10 years; P =ns) causing a longer disease duration (7.59-5 versus 4.49-4 years; P =0.016) at the time of clinical evaluation. These findings, although indirectly, suggest that C P infection of the central nervous system (C NS) might affect disease course in a subgroup of MS patients.
Url:
DOI: 10.1191/1352458503ms944oa
Affiliations:
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Filippi</name><affiliation wicri:level="3"><country xml:lang="fr">Italie</country><wicri:regionArea>Neuroimaging Research Unit, IRCCS Ospedale San Raffaele, Via Olgettina 58, 20100, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author wicri:is="90%"><name sortKey="Patti, F" sort="Patti, F" uniqKey="Patti F" first="F" last="Patti">F. Patti</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Neurological Department, University of Catania, Viale A. Doria 6, 95100, Catania</wicri:regionArea><wicri:noRegion>Catania</wicri:noRegion></affiliation></author><author wicri:is="90%"><name sortKey="Reggio, A" sort="Reggio, A" uniqKey="Reggio A" first="A" last="Reggio">A. Reggio</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Neurological Department, University of Catania, Viale A. 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Sforza 35, 20100, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author wicri:is="90%"><name sortKey="Comi, G" sort="Comi, G" uniqKey="Comi G" first="G" last="Comi">G. Comi</name><affiliation wicri:level="3"><country xml:lang="fr">Italie</country><wicri:regionArea>Neurological Department, IRCCS Ospedale San Raffaele, Via Olgettina 58, 20100, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author wicri:is="90%"><name sortKey="Blasi, F" sort="Blasi, F" uniqKey="Blasi F" first="F" last="Blasi">F. Blasi</name><affiliation wicri:level="3"><country xml:lang="fr">Italie</country><wicri:regionArea>Institute of Respiratory Diseases, University of Milano, IRCCS Ospedale Maggiore di Milano, Via F. Sforza 35, 20100, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Multiple Sclerosis</title><idno type="ISSN">1352-4585</idno><idno type="eISSN">1477-0970</idno><imprint><publisher>Sage Publications</publisher><pubPlace>Sage CA: Thousand Oaks, CA</pubPlace><date type="published" when="2003-10">2003-10</date><biblScope unit="volume">9</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="467">467</biblScope><biblScope unit="page" to="471">471</biblScope></imprint><idno type="ISSN">1352-4585</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1352-4585</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Amplification techniques</term><term>Cerebrospinal</term><term>Cerebrospinal fluid</term><term>Chlamydia</term><term>Chlamydia pneumoniae</term><term>Chlamydia pneumoniae infection</term><term>Clin microbiol</term><term>Clinical evaluation</term><term>Clinical relapse</term><term>Clinical specimens</term><term>Covariance analysis</term><term>Disease duration</term><term>Disease onset</term><term>Eds</term><term>Edss score</term><term>Latter hypothesis</term><term>Lesion</term><term>Lesional</term><term>Lesional load</term><term>Lumbar puncture</term><term>Mult scler</term><term>Multiple sclerosis</term><term>Neurol</term><term>Neurological controls</term><term>Ormerod score</term><term>Pneumoniae</term><term>Polymerase chain reaction</term><term>Sclerosis</term><term>Template preparation</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We amplified sequences of the Chlamydia pneumoniae (C P) major-outer membrane protein in the cerebrospinal fluid (CSF) from 23 of 107 (21.5%) relapsing-remitting or secondary progressive multiple sclerosis (MS) patients and two of 77 (2.6%) patients with other neurological diseases (OND) (P =0.00022). C P+ patients showed magnetic resonance imaging (MRI) evidence of more active disease (P =0.02) compared to CP-MS patients and tended to have an anticipation of age at disease onset (32.39-12 versus 28.59-10 years; P =ns) causing a longer disease duration (7.59-5 versus 4.49-4 years; P =0.016) at the time of clinical evaluation. These findings, although indirectly, suggest that C P infection of the central nervous system (C NS) might affect disease course in a subgroup of MS patients.</div></front></TEI><affiliations><list><country><li>Italie</li></country><region><li>Lombardie</li></region><settlement><li>Milan</li></settlement></list><tree><country name="Italie"><noRegion><name sortKey="Grimaldi, L Me" sort="Grimaldi, L Me" uniqKey="Grimaldi L" first="L Me" last="Grimaldi">L Me Grimaldi</name></noRegion><name sortKey="Allegra, L" sort="Allegra, L" uniqKey="Allegra L" first="L" last="Allegra">L. Allegra</name><name sortKey="Blasi, F" sort="Blasi, F" uniqKey="Blasi F" first="F" last="Blasi">F. Blasi</name><name sortKey="Comi, G" sort="Comi, G" uniqKey="Comi G" first="G" last="Comi">G. Comi</name><name sortKey="Filippi, M" sort="Filippi, M" uniqKey="Filippi M" first="M" last="Filippi">M. Filippi</name><name sortKey="Franciotta, D" sort="Franciotta, D" uniqKey="Franciotta D" first="D" last="Franciotta">D. Franciotta</name><name sortKey="Martinelli Boneschi, F" sort="Martinelli Boneschi, F" uniqKey="Martinelli Boneschi F" first="F" last="Martinelli-Boneschi">F. Martinelli-Boneschi</name><name sortKey="Patti, F" sort="Patti, F" uniqKey="Patti F" first="F" last="Patti">F. Patti</name><name sortKey="Pincherle, A" sort="Pincherle, A" uniqKey="Pincherle A" first="A" last="Pincherle">A. Pincherle</name><name sortKey="Reggio, A" sort="Reggio, A" uniqKey="Reggio A" first="A" last="Reggio">A. 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